What factor increases the radiosensitivity of tissues according to the Law of Bergonie and Tribondeau?

What factor increases the radiosensitivity of tissues according to the Law of Bergonie and Tribondeau?

• A. The rate of tissue healing
• B. The metabolic state of the tissue
• C. The method of radiation delivery
• D. The size of the area exposed

Answer: (B)

The factor that notably increases the radiosensitivity of tissues according to the Law of Bergonie and Tribondeau is the metabolic state of the tissue. This principle highlights that tissues that are actively dividing, those that have a high metabolic rate, and those that are less mature are more sensitive to radiation exposure. In a state of high metabolism, cells are more actively engaged in the processes of growth and division, which makes them more susceptible to the damaging effects of radiation. Radiation primarily affects DNA and cellular functions during these active phases, leading to higher chances of damage in rapidly dividing cells compared to those that are stable or quiescent. When considering the other factors, while the rate of tissue healing can play a role in the overall impact of radiation treatment, it is not directly linked to initial radiosensitivity. The method of radiation delivery and the size of the area exposed pertain more to the principles of radiation exposure rather than the inherent sensitivity of tissues to radiation itself. Thus, the metabolic state of a tissue is the key determinant in its radiosensitivity in line with the Law of Bergonie and Tribondeau.

The factor that notably increases the radiosensitivity of tissues according to the Law of Bergonie and Tribondeau is the metabolic state of the tissue. This principle highlights that tissues that are actively dividing, those that have a high metabolic rate, and those that are less mature are more sensitive to radiation exposure.

In a state of high metabolism, cells are more actively engaged in the processes of growth and division, which makes them more susceptible to the damaging effects of radiation. Radiation primarily affects DNA and cellular functions during these active phases, leading to higher chances of damage in rapidly dividing cells compared to those that are stable or quiescent.

When considering the other factors, while the rate of tissue healing can play a role in the overall impact of radiation treatment, it is not directly linked to initial radiosensitivity. The method of radiation delivery and the size of the area exposed pertain more to the principles of radiation exposure rather than the inherent sensitivity of tissues to radiation itself. Thus, the metabolic state of a tissue is the key determinant in its radiosensitivity in line with the Law of Bergonie and Tribondeau.